Oncologist Mikhail Blagosklonny devotes career to developing affordable cancer treatments

While many in phamaceutical research focus on the next money maker, oncologist Mikhail Blagosklonny uses the opposite approach. He has devoted his career to developing an affordable treatment for cancer with less side effects than current treatments.

One drug he studies shows promise in numerous uses, including cancer treatment. Rapamycin, also known as Sirolimus and Rapamune, received FDA approval as an organ transplant rejection drug, among other uses. The drug’s basis come from a bacterium found on Easter Island that researchers first isolated in 1972. Originally used as an anti-fungal agent, the pharmeceutical community abandoned this use when Rapamycin’s immunosuppressive and antiproliferative properties were uncovered. Read more on templeofthecave.com.

Blagosklonny, a professor of oncology at Rosewell Park Cancer Institute in Buffalo, New York, and Editor-in-Chief of Oncotarget, focuses his research on Rapamycin as a cancer and anti-aging drug. By anti-aging Blagosklonny refers to health longevity and disease fighting, not anti-wrinkling. The oncologist noticed that some cancers had a tendency to develop more often in older patients.

Rapamycin Current Uses

Rapamycin assists the body’s immune response to tumors and promotes tumor regression. Researchers have already discovered many other uses for Rapamycin, as well. Visit classroomvoices.org to read more about Mikhail.

Blagosklonny’s Further Research

  • As an immunosuppressant, it helps transplant patients’ bodies not reject an organ transplant. Rapamycin exhibits less toxicity on the kidneys over long-term use than other anti-rejection drugs.
  • It helps those with hemolytic-uremic syndrome, post kidney transplant in two ways. The disease combines anemia, kidney failure and low platelet count, leading to renal failure. Two treatment options exist: lifetime dialysis or a kidney transplant. Rapamycin helps the patient not reject the new kidney. It also helps the new kidney not develop the same disorder.
  • It blocks the mTOR signaling gateway in the lungs. This is key in treating a rare lung disease, lymphangioleiomyomatosis (LAM), that affects women of childbearing age. LAM causes mutations of the Tuberous Sclerosis Complex gene (TSC2) which activates the mTOR signaling gateway.
  • As a coronary stent coating, it helps prevent re-stenosis of the arteries after a balloon angioplasty.
  • As a suppressant for tumor development of Tuberous Sclerosis Complex (TSC), it helps reduce existing tumors. Research studies show that discontinuation of the drug results in tumor growth or re-devlopment. The congenital disorder causes benign tumors in organs such as the brain, heart and kidneys.
  • In cream, gel or ointment form, it treats facial angiofibromas, a disorder more than 80 percent of TSC patients also exhibit. While dermabrasion or laser facial treatments treat it cosmetically, Rapamycin, treats the development of the rash comprised of blood vessels and fibrous tissues.

Mikhail Blagosklonny recognizes that Rapamycin already has a multitude of uses beyond cancer. Despite a specialization as an oncologist, the doctor and researcher wants to uncover as many helpful uses for the drug as possible. To that end, he currently conducts studies of Rapamycin in relation to its potential to treat:

  • longevity due to enhanced disease fighting capabilities. Examples include its ability to help elderly mice fight tuberculosis and improve immunological performance in elderly humans when a dose of Rapamycin preceeded their influenza vaccination.
  • Alzheimer’s disease by preventing cognitive defects and reducing brain lesions in mice.
  • muscular dystrophy. In mice given nanoparticles coated with Rapamycin, the mice exhibited a 30 percent increase in grip strength and increased cardiac functions.
  • Systemic Lupus Erythematosus (SLE). In mice, it blocks and/or reverses the activation of mTORC1. That results in suppression of mTORC2.

Blagosklonny devotes his teaching, research and medical practice to finding an affordable treatment for cancer. He remains committed to discovering further use of Rapamycin for cancer treatment and treatment of other diseases.

Read: http://www.phillypurge.com/2017/07/14/oncotarget-mikhail-blagosklonny-rapamycin-incredible-healing-properties/

Barbara Stoke’s Construction Insights

Barbara Stokes is the current CEO of Green Structure Homes. Barbara and Scott Stoke founded the company in 2008 in Huntsville Alabama. Green Structure Homes is a disaster relief company which provides its solutions to both the government and the private sector. The company delivers its services by use of state of the art design and manufacturing styles.

Barbara Stokes together with GSH team has overtime proved to be reputable in the disaster rescue construction. She graduated From Mercer University where she pursued a bachelor of Physics and Biomedical Engineering in 2001. Also, she had the chance to continue with manufacturing management. At Mercer, she studied Technical Communications, Structures and properties of Materials and finally Thermodynamics. Read this article at businessinsider.com.

She ventured in GSH of Alabama after a thorough experience at Pisces Corporation. Barbara is also experienced in government contracting and is glad to have championed GSH in supporting FEMA’s mission in the United States of America. Barbara also gives back to the community and is a mother of three.

Green Structure Homes offers wood frames and steel homes. sGSH stands out from the unique art it employs including technology, homes that are energy efficient providing low budget and minimized time to build. Also, GSH delivers lower maintenance costs and primary insurance.

GSH of Alabama capitalizes on its unique art design and manufacturing styles when constructing its manufactured homes and multi-storeystructures. GSH team has combined the experience of more than a hundred years, and that contributes to accuracy and quality in production.

Read: http://www.cullmantimes.com/archives/green-structure-homes-alabama-to-be-cullman-s-newest-industry/article_5fc0baef-94dc-5d12-b35f-64a6caa41081.html

Administration logistics has an array of services which includes excellent facilities management, review of the maintenance documentation, maintenance of records which is electronic and visible on a secure portal, control of fleet which is electronically controlled and coordinating of scheduled services. GSH also provides its unique designs customized to meet the need for creativity in construction. The models include Bollards, Jackstands, Shelving and structures. The structures are one, two, three bedroomed units made of wood or steel construction products with the exterior of executive homes, and the interior can be customized to meet each of the customer’s needs and specifications. These apartments are very friendly to nature and pose little or no consequences to the site.

Less importation workforce works efficiently with GSH since products are manufactured locally. Upon arrival at the destination, the materials are erected within a few days leading to the final product possessing quality in construction. Read more about Barbara Stokes at WDRB.com.

Major Louis Chenevert’s Contributions at UTC

Among the key accomplishments made by Louis Chenevert while working at the UTC is towering of the 6’5” stature. This was during his reign as the president and CEO of the company since March 2006 to December 2014. During his position as a leader of the company, Louis is said to have been committed not only to utilizing advanced technology but also in people.

Since his first day at UTC, he made a pledge and a mission to make UTC a better company by taking it to heights against its competitors. It is true he lived to this pledge as he always made use of his knowledge and experience to make improvements in the company. Visit United Technologies website for more info.

 

He always believed in teamwork and emphasized on the fact that it is only through investment in the right technology and investing in the right people that a company can move forward. More to his stewardship in the company, Chenevert’s leadership was complete of Admirable qualities.

It is through his forward-thinking ability that Louis Chenevert managed to pick out projects with a potential to push the company’s vision. He was also a talented individual in inspiring his staff to work in making the projects a success.

He did not only apply these philosophies while at UTC but they are inborn characters to him that he perfects. Since he joined the world of career, he has always expressed admiration to companies that plan their future success through investing in equipment on the cutting edge of technological innovations.

View: http://www.bloomberg.com/research/stocks/people/person.asp?personId=191172&privcapId=159230

At one time through an interview, Louis was quoted saying modern-day success is entirely dependent on modern technology and this is all what he has been up to. In spite of having left UTC in 2014, the company always thanks him for the foundation he laid. Even after being succeeded by Gregory Hayes for the CEO position, UTC has remained to dominate the market.

More to this, the company, has continued enjoying vast of competitive advantages that were laid and implemented during his tenure. Surely, Chenevert left a legacy that continues to blossom and drive UTC particularly in fostering a competitive business environment for the company today. Read more about Louis Chenevert at wingsjournal.com.

TONY PETRELLO’S RISE TO PHILANTROPY

That there is a silver lining in every dark cloud is an adage well embodied in the life of Tony Petrello. Well concealed in the haze of hopelessness and frustration is a ray of light that with persistence serves to give hope and encouragement. Tony has defied the common portrayal of the rich as greedy, to rise as one of the celebrated philanthropists. He is famed for his giving towards medical research geared to developing a cure for neurological disorders common to new-borns.

Tony, as he is commonly referred to in his inner circle, is the President and CEO of Nabors Industries Limited. He joined Nabors in 1991 after resigning from a managerial position in Baker & McKenzie law firm. He has worked his way to the upper echelons of the World’s largest drilling company.

With a demanding career, Tony derives his strength from his disabled daughter. In 1997, Carena was prematurely born with Periventricular Leukomalacia. A disorder common among premature babies. The disorder’s characteristic of cutting oxygen supply to the baby’s brain led to Cerebral Palsy which inhibited Carena’s development. Consequently, Carena has had to put in extraordinary effort to perform tasks normal to other children such as eating, walking and speaking. Tony and his wife, Cynthia describe their daughter’s condition as a constant inspiration to them.

In the course of seeking medication for Carena, Tony realised a gap existed in medical research on such neurological disorders. This prompted him to explore the possibility of having a medical centre dedicated to research of childhood neurological disorders. The search led Tony to a neurological research facility in Texas, Texas Children’s Hospital. Tony has over the years made donations to the research facility that has seen the medical team make significant progress in managing the conditions.

Tony holds two degrees in Mathematics from Yale University and a Juris Doctor degree from Harvard school of law. In further philanthropism, Tony has been key in developing an annual prize at Yale University in remembrance of his late lecturer and friend, Professor Serge Lane. With his $ 150,000 initial gift and promising more, he envisions to set up an endowment fund to serve as a memorial to the Professor of Mathematics.

Tony is evidently a firm believer in getting elusive opportunities from challenges. His stint at Nabors Industries Limited has seen the drilling firm the grow to run over 500 oil rigs in 25 countries.

Learn More: people.equilar.com/bio/anthony-petrello-nbr/salary/503049#.WKHy57YrKRs

Beneful Brands at Walmart

Beneful is a company that millions of dog owners have become loyal to. This company provides dog food that is sold in a wide variety of choices at your local Walmart. This is one of the main reasons that so many people purchase this dog food for their pets. They know that they can find this when they go out to get other things from Walmart.

Some pet owners like to switch things up and give their dogs variety. Walmart has a lot of Beneful commercial choices for people that want to do this. There are Beneful Originals with real salmon that are sold at Walmart. There are also other choices like the Beneful Prepared meals. People have the chance to get bags of the Beneful 15 and a half pound bags for around $23. Many consumers consider this to be a very reasonable price for a bag of this size and more

 

Cameron Clokie: A Toronto Based Doctor Who Knows That Regenerative Medicine Has A Future

Stem cell therapy seems to be a simple idea, but in practice it is not always so simple. Regenerative medicine can take molecules and cells and fix problems in the body, but it is a sad truth that there have not been many regenerative medicine treatments as of yet. One of the earliest kinds of cell therapy was blood transfusion and then bone marrow transplants came along, which helped cancer patients. When a patient suffers from severe burns or scalds, it is possible to treat them with cell therapy that uses a person’s own cells to heal them. While this is true, regenerative medicine has still not become a mainstream tool.

Much progress is being made to heal common diseases and injuries through regenerative medicine, but despite the many successes it has had, many of its therapies are not being approved. Even with reports coming out that it has saved countless patients, the cost of many of the therapies are keeping it from being a mainstream tool. Dr. Cameron Clokie has commented on the fact that it is too bad that the costs are so high, because it is very likely that in the future the cost of regenerative medicine will come down making it an extremely valuable kind of medicine that more attention should be given to.

Cameron Clokie is a scientist, entrepreneur, and maxillofacial and oral surgeon who heads up Induce Biologics Inc. as its CEO. The company focuses its efforts on regenerative medicine and especially solving problems related to musculoskeletal reconstruction. As a writer, Dr. Clokie has published a spread of important papers related to the subjects of regenerative medicine and the rebuilding of bones.

Cameron Clokie has been working in clinical practice and academic dentistry for 30 years, and in 1998 he was given the title of Head of Oral and Maxillofacial Surgery at the University of Toronto. He was also promoted to Professor of Maxillofacial and Oral Surgery by the same Univeristy and remained so until 2017 when he retired from academia. As a businessman, Dr. Clokie has worked with businesses to turn some of his 25 patents and pending patents into real-world commercial applications.

Pioneering Businesswoman Susan McGalla

Susan McGalla is a business leader who pushed her way past barriers in the corporate world to become the first woman to obtain an executive position at American Eagle Outfitters, a company that was mostly male-dominated when she first started working at it. Because of her perseverance and determination, she ended up becoming the company’s president before she left it a few years later and founded her own business, which was called P3 Executive Consulting.

She attributes her many successes in leadership roles in the business world to the fact that she grew up in a household where she was the only girl. Having two brothers, and a father that was a football coach, she learned that she was not going to be given any special privileges just because of her gender, so she knew she’d have to work just as hard for what she wanted as her male family members did. She took that knowledge with her to every business position she’s held over the years, and she supports and motivates other women in business by encouraging corporate sponsors to use more advanced mentoring programs that she feels will be more effective for aspiring female executives than the ones that are normally implemented.

Susan McGalla received a Bachelor’s degree from Mount Union College, where she majored in Business and Marketing, and she still serves on the Board of Directors at the school. Before becoming the president at American Eagle Outfitters, she worked as a buyer for women’s clothing in the company. She also held the leadership role of CEO at a company called Wet Seal, Inc. Aside from running her consulting business, which provides expert advice to corporate clients on branding, marketing and management, she is currently the Vice President of Business Strategy and Creative Development for the Pittsburgh Steelers, a very popular NFL team.

She also sits on the board of HFF, Inc., a company that provides real estate services, and she continues to give motivational speeches and advice to women, as well as to people of all genders. Susan McGalla was born in East Liverpool, Ohio, and is married to Stephen McGalla, who is a wealth manager.

Find out more about Susan McGalla: http://www.phillypurge.com/2017/06/08/how-pittsburghs-susan-mcgalla-paved-the-way-for-women-in-leadership/

Meal Delivery Services For Athletes Like You

 

While you need to exercise and keep yourself moving, your diet is going to play a much more important role. You are what you eat after all and nutrition can make or break athleticism. There are meal delivery services meant to give you the advantage you need no matter what you want to do. These services allow you to choose from a variety of diets and assortments of meals, but you’ll have a good choice no matter what you choose to pursue. From the paleo diet to meat lovers, these meal delivery services have something for just about everybody.

 

 

Nutrisystem

 

Pure Health Living points to Nutrisystem for men as one of the most popular meal delivery services for a reason. It gives you just about everything you could want in your meal plan. You’ll have the perfect balance of protein, carbs, and vitamins for every single workout and routine. Unlike many other servers Nutrisystem makes sure you have a variety of options. You’ll have no problem bulking up if that’s what you want, but if you’re looking for a slimmer build the meal plans are designed to help those who want that as well.

 

 

Ice Age Meals

 

Not every athlete has the ability to cook and prepare a new meal every single day. That’s why athletes often need to think about freezing their meals and taking them out when they are prepared to eat. Ice Age Meals delivers kits specifically made to give you the convenience you want while providing the nutrition you need. The meals tend to have very long shelf lives and that makes them more than ideal for those who want to stock up ahead of time. You can even combine them with your own ideas to create the exact dish you want to eat.

 

 

Chef’d

 

Chef’d is emerging as a favorite among many athletes for its variety of gourmet meals. You can choose everything from fried chicken to pizza, but there’s plenty out there you’ve most likely never even thought about. The endless number of options makes this absolutely perfect for those who want to enjoy new meals while guaranteeing they’re still getting the nutrition they need as well. If you want risotto or sushi roll, you’ll have no problem finding a meal kit that offers this to you within the exact calorie range and nutritional profile you need to maintain your fitness and energy.

 

 

Paleo Power Meals

 

The most amazing thing about this diet is the balance and variety it offers you. The Paleo Diet is known as one of the most suitable diets for athletes, but finding meals specifically meant for your diet is often a hassle. This meal delivery service gives you a wide variety of options while still allowing you to stay within the Paleo Diet. It taps into the exact needs our bodies have while giving something we can truly enjoy. You’ll be surprised by what you can eat while maintaining the Paleo diet. This gives you just a few examples.

Realize Your Potential Through Nick Vertucci’s Real Estate Academy

For most self-made millionaires and billionaires, they have a life story where at one point their lives hit rock bottom. The difference between these people and any other middle-income earner is their ability to rise and shine even after going through the worst situations in life. They can see the opportunities when they present and dare to seize them. But you will need more than courage to become a millionaire; you need patient and consistency. You will need to have an unquenchable thirst for knowledge in your chosen filed to emerge as a winner.

Nick Vertucci is one such self-made millionaires who did all it took to provide for his family and still invest his time and resources to becoming who he is today. Nick was an average child growing up. He got all the necessary needs at every child deserves. Unfortunately, when he was ten years old, his father passed on. The mother was forced to do two jobs working long hours every day to provide to her family. In most cases, nick stayed up late at night with his siblings waiting for the mother. As if that was not enough, Nick had to go through another tough situation as a teenager. He lived in his truck for a while, but he never gave up.

He managed to start a business seeing computer parts. His venture was successful for a while. He got married and is a father of three daughters. Investing in technology has its ups and downs, during the dot-com rush of the year 2000, Nick was rendered jobless. His business collapsed. He started surviving on debt and struggled daily to provide for his young family.

While still looking for greener pastures, Nick was invited by his friend to attend a real estate investment class. He developed a deep interest in the field and kept learning all the skills. His decision to participate in that class is what has made him a real estate guru today. He founded Nick Vertucci Real Estate Academy in the year 2013 after retiring from the police force. Through this academy, Nick accepts students who have a deep interest in real estate and using the best real estate professionals. They are taught how to make money in this field that is dominated by rich people.

Nick simplified the real estate skill into a simple Get In, Get Out and Get paid, model. Where you are taught how to buy a property at a low price, add value to it and finally sell it at a profit. Nick Vertucci is also the host of a radio a radio program “The Real Estate Flipping Hour.”

Felipe Montoro Jens Speaks Of the Last Bullets in Keeping Pace with Technological Migration

Brazil has really hit a hard snug in the past economic recession, but it felt the pinch the more altogether. This is because they had not put up measures to curb the diverse effects of these fluctuations. Among the countries in its region it is lagging behind and something impactful need to be done with speed.

Felipe Montoro Jens who is a management and infrastructure expert says the initial action should be the public, private partnerships that will bring in modernization and civilization in selected key sectors of the economy. He is currently in talks with Nelson Marchezan Junior who is tasked in fostering these partnerships through the Management Council of the Municipal Program of Partnerships.

They have prioritized key areas where privatization is really needed. These include the sanitation and public clocks, marketplace, lighting, Water Park and in health care they will revamp the Hospital Materno Infantil Presidente Vargas which primarily deals with pediatrics. Nelson Marchezan being the municipal’s mayor will moderate the project and inform the government of sectors that need to be addressed with urgency.

About Felipe Montoro Jens

He is in cognition for spearheading monumental structures and architectural works. Although he is largely in management he is a hands-on leader who doesn’t shy away from task should he be needed to do them himself. Felipe Montoro Jens is the President and Chief Executive Officer of the energy based company, Energipar Captacao.

Elsewhere, Felipe Montoro has worked in various industries including telecommunication, finance, and transport. At one time the national government appointed him to be in charge of the treasury, a wing of the Economic and Social Development. He has become a face to reckon in Brazil. Felipe Montoro is a graduate of Fundao Getilo Vargas in International Management a background that shaped his career in finance.

Read more about Felipe Montoro Jens: http://maringa.odiario.com/politica/2017/06/por-que-privatizar-segundo-estudo-da-cni-com-felipe-montoro-jens/2384962/